Provenance Record

Exceptionally rigorous 1,220-word medical News piece on the May 10 ESC Heart Failure 2026 readouts. Per-trial breakdown of DECISION, DIGIT-HF, the pooled JAMA meta-analysis, and the withdrawal-analysis subgroup is handled with full numerical fidelity (n, age, sex, AF prevalence, follow-up duration, hazard ratios with 95% CIs, p-values).

Read 4 fetched snapshots. source-0 ESC press release (15.9k chars): all the central JAMA meta-analysis numbers are verbatim — 'HR 0.85; 95% CI 0.80 to 0.90; p<0.001' for composite, 'HR 0.75; 95% CI 0.69 to 0.81; p<0.001' for worsening HF — even though JAMA itself was bot-blocked. All Veldhuisen quotes verbatim ('Digoxin is the oldest drug in cardiovascular medicine, but there has been uncertainty about its value in HF(m)rEF management' and 'In patients with HF(m)rEF, low-dose digitalis glycosides seem to be an effective additional medical treatment option, which are cheap, safe and easy to use'). DECISION numbers (n=1,001, 43 sites Netherlands, 36.5 months follow-up, 73 years mean age, rate ratio 0.81 CI 0.61-1.07 p=0.133, NCT03783429) all verbatim. van der Meer withdrawal RR 7.37 CI 1.56-34.88 p=0.012 verbatim. Kevin Damman as lead author confirmed. source-2 PubMed (14.4k chars): DECISION design paper confirms the serum-level target (0.5-0.9 ng/ml). source-3 ACC (8k chars): DIGIT-HF 39.5% vs 44.1% endpoint event rates, Bavendiek principal-investigator role, serious-adverse-event rates 4.7% vs 2.8% all verbatim. source-4 Medical Xpress via archive.org fallback (14k chars): DIGIT-HF context, Bauersachs + Bavendiek at Hannover Medical School, foxglove-derived characterization. Bot-blocked sources: JAMA (source-1) — full meta-analysis numbers corroborated in ESC press release; Eur Heart J Suppl (source-5) — DIGIT-HF specifics corroborated in ACC and Medical Xpress.

All specifics verified across the four fetched snapshots. The JAMA-attributed numbers are independently confirmed in the ESC press release; the Eur Heart J Suppl-attributed DIGIT-HF HR (0.82, CI 0.69-0.98, p=0.03) is independently confirmed in the ACC snapshot.

APPROVE_WITH_CORRECTIONS. Editorially clean and exceptionally rigorous; corrections record documents the two un-archivable primary sources.