Provenance Record

Well structured (Overview / What We Know / What We Don't Know / Analysis). Neutral tone with appropriate scientific caution. No AI self-reference. Length appropriate for News (863 words).

{"source-0":{"url":"https://healthcare.utah.edu/newsroom/news/2026/05/new-kind-of-crispr-could-treat-viral-infection-and-cancer-shredding-sick","snapshot":"source-0.html.gz","status":"Primary press release from University of Utah Health. Verifies: 50% reduction in KRAS-mutant cells, 90% in HPV cells, cisplatin comparison, Yang Liu and Jared Thompson quotes verbatim, 'curing the incurables' closing quote. Does NOT specify KRAS variant (G12C) or HPV transcripts (E6/E7)."},"source-1":{"url":"https://www.helmholtz-hzi.de/en/media-center/newsroom/news-detail/like-a-molecular-scalpel-new-crispr-tool-eliminates-undesired-cells-with-ease/","snapshot":"source-1.html.gz","status":"Helmholtz / HIRI press release. Verifies: Ryan Jackson 'shreds all DNA / effectively killing the cell' quote verbatim, Paul Scholz 'sequence-specific depletion of pathogenic cells' quote, G-dase-E nuclease, Akribion's HPV-positive H&N cancer lead program with in vivo-PoC + PDC nomination planned for 2026, DOI 10.1038/s41586-026-10466-y, 2023 prior Nature paper reference, full list of collaborators."},"source-2":{"url":"https://attheu.utah.edu/health-medicine/new-kind-of-crispr-could-treat-viral-infection-and-cancer-by-shredding-sick-cells-dna/","snapshot":"source-2.html.gz","status":"University of Utah campus news. Verifies Jared Thompson 'For as long as medicine has been practiced...' quote verbatim and the May 6 Nature publication date with the paper title."}}

Core science story (May 6 Nature paper introducing Cas12a2 as an RNA-triggered DNA-shredding nuclease for cancer and viral cells) is solid: every direct quote (Liu, Thompson, Jackson, Scholz, 'curing the incurables') is verbatim in the cited snapshots; all major quantitative findings (50% reduction in KRAS-mutant cells, 90% in HPV-infected cells, cisplatin comparison), all collaborating institutions (HIRI, Würzburg, Akribion, U Utah, USU, Huntsman, BRAIN Biotech), the DOI, and the May 6 Nature publication date are verified. Several technical specifics (KRAS variant 'G12C', HPV transcripts 'E6/E7', '3- to 4-fold' enrichment, ASGCT 2026 Boston May 11–15) appear in the article without being in the cited press releases — likely from the Nature paper itself, but should be sourced. APPROVE_WITH_CORRECTIONS with a detailed corrections record.