Provenance Record

Exceptionally well structured (Overview / What We Know with three sub-sections / What We Don't Know / cross-reference). Neutral, professional tone. Length appropriate for News. Strong adherence to Rule 9: both Nature Biotechnology DOIs cited in article.sources and inline. The Hsing 'address/car' quote is the only specific exclusively from a bot-blocked source.

{"source-0":{"url":"https://news.ufl.edu/2026/05/dna-guided-crispr/","snapshot":"source-0.html.gz","status":"UF News (May 15, 2026). Verifies: Piyush Jain (Shah Rising Professor, Chemical Engineering), all three co-first authors (Orosco, Huang, Rananaware), UT Austin + Princeton collaborations, full Xerox-copies/cheaper-easier/orders-of-magnitude/great-deal-of-persistence/challenged-conventional quotes verbatim, hepatitis C 100% accuracy, HIV early detection."},"source-1":{"url":"https://phys.org/news/2026-05-discovery-reshape-rna-dna-crispr.html","snapshot":null,"status":"BOT-BLOCKED (HTTP 403). Article cites this for UF paper coverage including DOI, 'within a few years' timeline, and 'orders of magnitude' framing. ALL specifics attributed to this URL are also independently in source-0 (UF News) and source-5 (Nature DOI) — provenance chain intact even though Phys.org URL itself is unverifiable."},"source-2":{"url":"https://phys.org/news/2026-05-dna-crispr-flips-gene-script.html","snapshot":null,"status":"BOT-BLOCKED (HTTP 403). Article cites this for HKUST paper coverage including the 'RNA guide molecule is like the address you type in' Hsing quote, the SLEUTH crDNA mechanism, the AlphaFold/MD/cryo-EM methodology, and the Cas13 comparison. The methodology and the Cas13 comparison are independently in source-3 (HKUST release); the Hsing 'address/car' quote is only in s2."},"source-3":{"url":"https://hkust.edu.hk/news/hkust-researchers-flip-crispr-script-develop-worlds-first-dna-guided-gene-editing-tool-precise","snapshot":"source-3.html.gz","status":"Official HKUST press release. Verifies: Hsing I-Ming + Zhai Yuanliang affiliations, all three co-first authors (Wu Xiaolong, Lam Wai-Hei, Cao Yumeng), SLEUTH (Specific Locus Evaluation Utilizing Targeted Hydrolysis), 31 clinical SARS-CoV-2 samples, attomolar sensitivity for RNA + DNA, two US provisional patents, three-year roadmap, liquid biopsy + circulating-RNA-biomarkers expansion, AlphaFold + MD + cryo-EM, 'significantly less off-target RNA cleavage' than Cas13."},"source-4":{"url":"https://www.miragenews.com/crispr-revolution-dna-guided-tool-for-disease-1668488/","snapshot":"source-4.html.gz","status":"Mirage News. Verifies the cold-chain storage point and the single-nucleotide discrimination claim attributed to the HKUST team."},"source-5":{"url":"https://www.nature.com/articles/s41587-026-03129-w","snapshot":"source-5.html.gz","status":"Primary publication: UF team paper 'DNA-guided CRISPR–Cas12 for cellular RNA targeting'. Title verified. Cited directly in the article per Rule 9 — exemplary primary-publication discipline."},"source-6":{"url":"https://www.nature.com/articles/s41587-026-03120-5","snapshot":"source-6.html.gz","status":"Primary publication: HKUST team paper 'DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage'. Title verified. Cited directly per Rule 9."}}

High-quality dual-paper coverage with strong primary-publication discipline (Rule 9). Both Nature Biotechnology DOIs are in article.sources and cited directly. Every quoted material (Jain's 'Xerox copies', 'cheaper and easier to manufacture', 'orders of magnitude', Orosco's 'great deal of persistence...challenged conventional thinking') verified verbatim against source-0 (UF News). All HKUST specifics — SLEUTH acronym expansion, 31 SARS-CoV-2 clinical samples, attomolar sensitivity, two US provisional patents, three-year roadmap, liquid biopsy direction, AlphaFold + MD + cryo-EM methodology, Cas13 off-target comparison — verified verbatim against source-3. The UF team's collaborators (UT Austin, Princeton) and co-first authors (Orosco, Huang, Rananaware) verified. The 100% hepatitis C accuracy and HIV early detection claims verified in source-0 directly (not just Phys.org). Internal cross-reference to 2026-05/15-rna-triggered-crispr-system... verified to exist.