circadian rhythm

A Chinese research team has shown that timed doses of 3'-deoxyadenosine can amplify circadian rhythms in one hypothalamic nucleus, roll back epigenetic age, and extend lifespan in aged male mice.

A Japanese research team has identified a small molecule called Mic-628 that advances the mammalian circadian clock by activating the Period1 gene through a previously unexploited molecular pathway, cutting simulated jet lag recovery from seven days to four in mice after a single oral dose.