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The RUBY trial of renizgamglogene autogedtemcel (reni-cel), a one-time CRISPR-Cas12a gene-editing therapy, showed that 27 of 28 patients with severe sickle cell disease had no painful crises after treatment, with hemoglobin levels normalizing to 13.8 g/dL by six months.
A KIST-IAE team engineered a tungsten diselenide catalyst that achieved over 550 stable cycles in lithium-air batteries, outperforming conventional catalysts and advancing a technology with ten times the energy density of lithium-ion.
A fossil assemblage preserved as carbonaceous films in Yunnan Province reveals more than 700 specimens of complex animals, including the oldest known deuterostomes, dating to 554-539 million years ago and closing a major gap between the Ediacaran period and the Cambrian explosion.
Legged metamachines evolved by AI traverse rugged terrain, self-right when flipped, and continue operating after losing limbs, in research published in PNAS.
Researchers combine amplitude, phase, and polarization in a single holographic data page, using a neural network to decode all three channels from intensity-only measurements.
Stockholm University physicists used ultra-fast X-ray pulses to confirm a second critical point in supercooled water at -63 degrees Celsius and 1,000 atmospheres, explaining why water behaves unlike any other liquid.
A study of nearly 250,000 U.S. adults finds the shingles vaccine dramatically reduces heart attacks, strokes, and deaths in people with existing cardiovascular disease.
Kyushu University and JGU Mainz researchers use a molybdenum-based spin-flip emitter to surpass the one-photon-one-electron limit, reaching 130% quantum yield with a theoretical ceiling of 200%.
UCL and Great Ormond Street Hospital scientists built a functional oesophagus from a donor scaffold and the recipient's own cells, restoring normal eating in eight pigs within six months.
ARPA-H has awarded up to $176.8 million to five teams building 3D-bioprinted kidneys and livers designed to work without immunosuppressive drugs, targeting first-in-human trials within five years.
A team led by North Carolina State University has demonstrated that magnetizing patterned elastic polymer sheets turns their chaotic snapping behavior into repeatable, sequential unfolding, boosting kinetic energy absorption by 30 percent.
Gene-edited pig kidneys have entered FDA-cleared clinical trials, a $176.8 million federal program is funding five teams to bioprint livers, and new cryopreservation methods could extend organ viability from hours to days.