pubmed.ncbi.nlm.nih.gov

An Fc-engineered CD40 agonist injected into a single tumor triggered systemic immune responses that eliminated cancer across the body in two patients, with expanded trials now under way at Memorial Sloan Kettering and Duke.

A Nature study finds that star-shaped brain cells called astrocytes encode, maintain, and regulate fear memories alongside neurons, opening new paths for PTSD treatment.

A Nature paper describes INSTALL, a gene editing platform using circular single-stranded DNA to insert therapeutic genes without triggering fatal immune responses, keeping mice healthy at doses where conventional DNA proved lethal.