Biotech & Medicine
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Cauldron Ferm Raises $13.25 Million to Scale Continuous Hyper-Fermentation Platform Beyond 10,000-Liter Demonstration
Australian biomanufacturing startup Cauldron Ferm has closed a $13.25 million Series A2 round to expand its continuous hyper-fermentation platform, which it claims reduces unit costs by up to 50 percent and capital expenditure by 45 percent compared to conventional batch processes.
Neuralink Demonstrates Thought-to-Speech in ALS Patient as VOICE Trial Begins Decoding Silent Neural Signals
Neuralink's VOICE trial decoded silent neural signals from an ALS patient's brain into synthesized speech as the company's BCI program scales to 21 participants worldwide.
Restoring a Single Brain Clock Reverses Aging Biomarkers and Extends Lifespan in Mice, Cell Study Finds
A Chinese research team has shown that timed doses of 3'-deoxyadenosine can amplify circadian rhythms in one hypothalamic nucleus, roll back epigenetic age, and extend lifespan in aged male mice.
Texas Commits $50 Million to Largest State-Funded Ibogaine Clinical Trial After Drug Companies Fail to Meet Partnership Terms
Texas will fully fund a $50 million ibogaine trial through 11 universities after no drug company met partnership terms, targeting PTSD, addiction, and TBI in veterans.
Envoy Medical Reports First Patients Reaching 12-Month Endpoint in Pivotal Trial of Fully Implanted Cochlear Implant
Three participants in the Acclaim cochlear implant trial have completed their primary 12-month evaluations, bringing the first fully implanted cochlear implant closer to FDA submission.
ARPA-H Awards $144 Million to Seven Teams Racing to Prove FDA-Approved Drugs Can Extend Human Healthspan
The US government's health research agency has funded the first large-scale clinical trials testing whether rapamycin, semaglutide, and other repurposed drugs can slow biological aging in healthy adults, with results expected within three years.
Butterfly Network Wins First FDA Clearance for a Blind-Sweep Ultrasound AI That Estimates Gestational Age Without a Trained Sonographer
The FDA has cleared Butterfly Network's Gestational Age Tool, the first blind-sweep ultrasound AI authorized for U.S. marketing, letting any healthcare worker estimate fetal age in under two minutes.
Stanford and Arc Institute Trace Age-Related Memory Loss to a Single Gut Bacterium, Then Reverse It via the Vagus Nerve
A Nature study identifies Parabacteroides goldsteinii as a driver of cognitive decline in aging mice and shows that stimulating the vagus nerve with GLP-1 receptor agonists restores memory to youthful levels.
Editas Medicine's CRISPR-Cas12a Therapy Achieves Functional Cure in 27 of 28 Sickle Cell Patients as RUBY Trial Results Land in NEJM
The RUBY trial of renizgamglogene autogedtemcel (reni-cel), a one-time CRISPR-Cas12a gene-editing therapy, showed that 27 of 28 patients with severe sickle cell disease had no painful crises after treatment, with hemoglobin levels normalizing to 13.8 g/dL by six months.
Lab-Grown Leather Derived From T. Rex Collagen Debuts as a Luxury Handbag in Amsterdam, Drawing Paleontologist Pushback
A collaboration between VML, The Organoid Company, and Lab-Grown Leather Ltd. has produced the first handbag from material engineered using reconstructed Tyrannosaurus rex collagen sequences, but paleontologists challenge the project's scientific framing.
Rockefeller's Redesigned CD40 Antibody Eliminates Metastatic Cancers in Phase 1 Trial, Sparking Nearly 200-Patient Expansion
An Fc-engineered CD40 agonist injected into a single tumor triggered systemic immune responses that eliminated cancer across the body in two patients, with expanded trials now under way at Memorial Sloan Kettering and Duke.
NIH Study Reveals Astrocytes Actively Shape Fear Memory in the Amygdala, Challenging Decades of Neuron-Centric Models
A Nature study finds that star-shaped brain cells called astrocytes encode, maintain, and regulate fear memories alongside neurons, opening new paths for PTSD treatment.